Once in a while you’ll get users on community support channels which may flood your private queries with support questions – even if told not to do so (ignorance is bliss, eh?). The simplest way is still /ignore but i prefer to have it globally configured in irssi.
$ vim .irssi/config ignores = ( { mask = "MosquitoCR"; level = "ALL"; }, );
Silence … ikillu! 😉