Since I’m trying to avoid any boot of MS OS a short howto…
Mount ISO/MDF with the following command
mount -t iso9660 -o loop /mnt/bla/bla.mdf /media/image
Then get Wine (using apt or src)
Start Installer with Wine, go through like on Windows and then try to start the game. More Information which games are working can be found on http://appdb.winehq.org